BDBM331223 5-(Dimethyl-1H-1,2,3-triazol-5-yl)-10-methanesulfonyl-8-[(S)-oxan-4-yl(phenyl)methyl]-13-(propan-2-yloxy)-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1(13),2::US9725449, Example 57::US9725449, Example 58

SMILES CC(C)Oc1ncc(c2n([C@@H](C3CCOCC3)c3ccccc3)c3cc(cnc3c12)-c1c(C)nnn1C)S(C)(=O)=O

InChI Key InChIKey=ZHSVCOZTFAYDER-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331223   

LigandPNGBDBM331223(5-(Dimethyl-1H-1,2,3-triazol-5-yl)-10-methanesulfo...)
Affinity DataIC50: 1nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM331223(5-(Dimethyl-1H-1,2,3-triazol-5-yl)-10-methanesulfo...)
Affinity DataIC50: 1nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In DepthDetails
US Patent