BDBM330295 Methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate ::US9724352, I-33

SMILES COC(=O)Nc1cc(c(cn1)-c1nc(N2CCOCC2)c2cc(CN3CCN(CC3)S(C)(=O)=O)cn2n1)C(F)(F)F

InChI Key InChIKey=KTLQDDGRBDLKMN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 330295   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 2.84nMAssay Description:The activity of purified kinase was detected with Kinase-Glo Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant c-Raf Y340D/Y341D mutant (306 to end residues) using inactive MEK1 as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 598nMAssay Description:Inhibition of human PI3K p110beta/p85alpha using PIP2 as substrate incubated for 40 mins in presence of ATP measured after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 79nMAssay Description:Inhibition of human PI3K p110delta/p85alpha using PIP2 as substrate in presence of ATP measured after 40 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human full length recombinant mTOR in presence of [gamma33P-ATP] by radiometric scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM330295(US9724352, I-33 | Methyl (5-(6-((4-(methylsulfonyl...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed