BDBM330259 5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo [2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine::US9724352, I-27

SMILES CS(=O)(=O)N1CCN(Cc2cc3c(nc(nn3c2)-c2cnc(N)cc2C(F)(F)F)N2CCOCC2)CC1

InChI Key InChIKey=UFAGCJATMFYIDR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 330259   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM330259(US9724352, I-27 | 5-(6-((4-(methylsulfonyl)piperaz...)
Affinity DataIC50: 8.37nMAssay Description:The activity of purified kinase was detected with Kinase-Glo Plus kinase luminescent assay by measuring the amount of the remaining Kinase in the sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

LigandPNGBDBM330259(US9724352, I-27 | 5-(6-((4-(methylsulfonyl)piperaz...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human PI3Kalpha using PIP2 as substrate in presence of ATP measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed