BDBM330054 (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,5-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide::US10689399, Compound 64::US11548901, Compound 64::US9663528, 64::US9732092, Compound 64

SMILES Oc1c2C(=O)N3[C@H]4CC[C@H](C4)O[C@@H]3Cn2cc(C(=O)NCc2cc(F)c(F)cc2F)c1=O

InChI Key InChIKey=MMQRKCJAYXYWHZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 330054   

TargetSolute carrier family 22 member 2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM330054(US9663528, 64 | US9732092, Compound 64 | (2R,5S,13...)
Affinity DataIC50: 94nMAssay Description:The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
Go to US Patent

TargetSolute carrier family 22 member 2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM330054(US9663528, 64 | US9732092, Compound 64 | (2R,5S,13...)
Affinity DataIC50: 94nMAssay Description:Test compounds were serially diluted in DMSO and then spiked (2 μL) into in 0.4 mL KHB buffer containing wild-type or OCT2-transfected cells and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetPOU domain, class 2, transcription factor 2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM330054(US9663528, 64 | US9732092, Compound 64 | (2R,5S,13...)
Affinity DataIC50: 94nMAssay Description:The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
Go to US Patent

TargetSolute carrier family 22 member 2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM330054(US9663528, 64 | US9732092, Compound 64 | (2R,5S,13...)
Affinity DataIC50: 94nMAssay Description:The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
Go to US Patent