BDBM329828 (rac)-((1R,2R,3S,4R)-2,3-Dihydroxy-4-((2-(3-(pyridin-2-yl)phenyl)pyrazolo[1,5-::US10202389, Compound I-036::US9663525, Compound I-036::US9796725, Compound I-036

SMILES NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc(c2)-c2ccccn2)[C@H](O)[C@@H]1O

InChI Key InChIKey=ZDZZITXJLONZJL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 329828   

TargetUbiquitin-conjugating enzyme E2 E1(Human)
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM329828(US9663525, Compound I-036 | (rac)-((1R,2R,3S,4R)-2...)
Affinity DataIC50: 10nMAssay Description:The UAE enzymatic reaction totals 50 μL and contains 50 mmol HEPES (pH 7.5), 0.05% BSA, 2.5 mM MgCl2, 0.1 uM ATP, 8 nM GST-Ubc-2, 35 nM flag-ubi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetUbiquitin-like modifier-activating enzyme 1(Human)
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM329828(US9663525, Compound I-036 | (rac)-((1R,2R,3S,4R)-2...)
Affinity DataIC50: 10nMAssay Description:The UAE enzymatic reaction totals 50 μL and contains 50 mmol HEPES (pH 7.5), 0.05% BSA, 2.5 mM MgCl2, 0.1 uM ATP, 8 nM GST-Ubc-2, 35 nM flag-ubi...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSUMO-activating enzyme subunit 2(Human)
Millennium Pharmaceuticals

US Patent
LigandPNGBDBM329828(US9663525, Compound I-036 | (rac)-((1R,2R,3S,4R)-2...)
Affinity DataIC50: 10nMAssay Description:he UAE enzymatic reaction totals 50 μL and contains 50 mmol HEPES (pH 7.5), 0.05% BSA, 2.5 mM MgCl2, 0.1 uM ATP, 8 nM GST-Ubc-2, 35 nM flag-ubiq...More data for this Ligand-Target Pair
In DepthDetails
US Patent