BDBM325835 BDBM50075053::US10273223, Compound A-29::US9637472, Compound A-29
SMILES CC(C)n1ncc2c(cc(nc12)-c1ccc2OCCOc2c1)C(=O)NCc1c(C)cc(C)[nH]c1=O
InChI Key InChIKey=JJTHXXIHNSDTDZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 325835
TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 620nMAssay Description:Inhibition of human EZH2 using SAM and histone H3 (16 to 30) as substrate preincubated for 30 mins followed by substrate addition measured after 90 m...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 650nMAssay Description:Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 650nMAssay Description:eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKi: 310nMAssay Description:Inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine and biotinylated histone peptides as substrateMore data for this Ligand-Target Pair