BDBM32334 7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydrobenzofur[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydrobenzofuro[2,3-c]azepin-1-one::7-oxidanyl-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one::MLS000043346::SMR000019965::cid_755673

SMILES Oc1ccc2oc3c(CCCNC3=O)c2c1

InChI Key InChIKey=AACFPJSJOWQNBN-UHFFFAOYSA-N

Data  16 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 32334   

TargetSerine/threonine-protein kinase PLK1(Human)
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 2.03E+4nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 182nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetPolycystin-2(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant PKD2 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D3(Human)
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 227nMpH: 7.5 T: 2°CAssay Description:The radiometric kinase assay using PKD kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D2(Human)
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 280nMpH: 7.5 T: 2°CAssay Description:The radiometric kinase assay using PKD kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 182nMpH: 7.5 T: 2°CAssay Description:The radiometric kinase assay using PKD kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 5.00E+4nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 1.53E+4nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 742nMpH: 7.2 T: 2°CAssay Description:The PKD HTS assay was developed and run at the University of Pittsburgh Molecular Screening Center (PMLSC) as part of the Molecular Library Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 500nMAssay Description:An IMAP-based PKD HTS FR assay was used for primary HTS of the PMLSC library to identify hit compounds and subsequent secondary hit confirmation stud...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D3(Human)
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 227nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D2(Human)
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 280nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 182nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataEC50:  2.07E+3nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase 33(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataEC50:  3.71E+3nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase PLK1(Human)
University of Pittsburgh

LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 1.67E+4nMAssay Description:The PKD HTS assay was developed and run at the University of Pittsburgh Molecular Screening Center (PMLSC) as part of the Molecular Library Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32334(7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]az...)
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase HTS dose response confirmation has been developed to confirm actives identified in the Cdc25B HTS AID 368, screened at the Uni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay