BDBM322547 2-Methyl-4-[3-(5-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-pyridine::US10183939, Example 21::USRE49361, Example 21

SMILES Cc1cc(Oc2ccc3OCC(Cc3c2)c2ncc([nH]2)-c2ccccc2)ccn1

InChI Key InChIKey=FMJUUVBHMGLOJG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 322547   

LigandPNGBDBM322547(2-Methyl-4-[3-(5-phenyl-1H-imidazol-2-yl)chroman-6...)
Affinity DataIC50: 52nMAssay Description:To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322547(2-Methyl-4-[3-(5-phenyl-1H-imidazol-2-yl)chroman-6...)
Affinity DataIC50: 52nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM322547(2-Methyl-4-[3-(5-phenyl-1H-imidazol-2-yl)chroman-6...)
Affinity DataIC50: 52nMAssay Description:B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM322547(2-Methyl-4-[3-(5-phenyl-1H-imidazol-2-yl)chroman-6...)
Affinity DataIC50: 52nMAssay Description:B-RAF, RAFV600E, and C-RAF: Compounds at a concentration of 3 mM are serially diluted (e.g. 10 μl, 90 μl of 100% dimethyl sulfoxide (DMSO))...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent