BDBM321458 6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbonyl)phenyl]-1H-pyrrolo[2,3-c]pyridin-7-one::US10183009, Example 48

SMILES Fc1cc(cc(C(=O)N2CCOCC2)c1F)-c1cn(CCC=C)c(=O)c2[nH]ccc12

InChI Key InChIKey=ICIIHYCMSRJMHI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 321458   

TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM321458(6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbo...)
Affinity DataIC50: 17nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321458(6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbo...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM321458(6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbo...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM321458(6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbo...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321458(6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbo...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321458(6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbo...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321458(6-but-3-enyl-4-[3,4-difluoro-5-(morpholine-4-carbo...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant His-tagged BRD9 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed