BDBM32142 5-amino-8-quinolinol::5-aminoquinolin-8-ol::5-azanylquinolin-8-ol::AS-0308-225::cid_416002

SMILES Nc1ccc(O)c2ncccc12

InChI Key InChIKey=YDEUKNRKEYICTH-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 32142   

TargetHeat shock protein HSP 90-alpha(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 2.76E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details
PCBioAssay
TargetHeat shock protein HSP 90-alpha(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 1.56E+3nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details
PCBioAssay
TargetHeat shock protein HSP 90-alpha(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Emory Chemistry-Biology Discovery Center Assay Overview: MLSCN Grant: 1 X01MH78953-01 Hsp90 is a chaperon with important roles in maintaining transfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2011
Entry Details
PCBioAssay
TargetHeat shock protein HSP 90-alpha(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Emory Chemistry-Biology Discovery Center Assay Overview: MLSCN Grant: 1 X01MH78953-01 Hsp90 is a chaperon with important roles in maintaining transfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2011
Entry Details
PCBioAssay
TargetProteasome subunit beta type-5(Human)
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human UTMC2 cells assessed as free 7-amino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2017
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KMH11 cells assessed as free 7-amino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2017
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KMS18 cells assessed as free 7-amino...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2017
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human OCI-AML2 cells assessed as free 7-am...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2017
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human NB4 cells assessed as free 7-amino-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2017
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KG1A cells assessed as free 7-amino-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2017
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human MDAY-D2 cells assessed as free 7-ami...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2017
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human K562 cells assessed as free 7-amino-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2017
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Mouse)
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse recombinant IDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM32142(cid_416002 | 5-amino-8-quinolinol | AS-0308-225 | ...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of IDO1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed