BDBM321411 6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-carbonyl)phenyl]-2-methyl-1H-pyrrolo[2,3-c]pyridin-7-one::US10183009, Example 94

SMILES COc1cc(ccc1C(=O)N1CCOCC1)-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12

InChI Key InChIKey=AVBQIZYXLUVYRI-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 321411   

TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM321411(6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-ca...)
Affinity DataIC50: 3nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321411(6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-ca...)
Affinity DataIC50: 6nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged BRD9 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321411(6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-ca...)
Affinity DataIC50: 3.30E+3nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged BRD4 bromodomain 1 (unknown origin) measured after 10 mins by TR-FRET ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321411(6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-ca...)
Affinity DataIC50: 1.74E+4nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged BRD4 bromodomain 2 (unknown origin) measured after 10 mins by TR-FRET ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321411(6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-ca...)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged CECR2 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM321411(6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-ca...)
Affinity DataIC50: 1.70E+3nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged TAF1 bromodomain 2 (unknown origin) measured after 10 mins by TR-FRET ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321411(6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-ca...)
Affinity DataEC50:  10nMAssay Description:Binding affinity to ZsGreen fused-BRD9 (M1 to T597 residues) (unknown origin) expressed in human U2OS-C433 cells assessed as induction of protein bro...More data for this Ligand-Target Pair
In DepthDetails
PubMed