BDBM321107 (S)-ethyl (8-((2-amino-2,4-dimethylpentyl)oxy)-6H-isochromeno[3,4-c]pyridin-2-yl)carbamate::US10174044, Example 41

SMILES CCOC(=O)Nc1cc-2c(OCc3cc(OC[C@@](C)(N)CC(C)C)ccc-23)cn1

InChI Key InChIKey=MWHCLYMKQNOMIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 321107   

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM321107((S)-ethyl (8-((2-amino-2,4-dimethylpentyl)oxy)-6H-...)
Affinity DataIC50: 0.620nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM321107((S)-ethyl (8-((2-amino-2,4-dimethylpentyl)oxy)-6H-...)
Affinity DataIC50: 0.620nMAssay Description:Inhibition of thrombin-recognition site-fused GST-tagged human AAK1 expressed in bacterial expression system using 5-FAM-Aha-KEEQSQITSQVTGQIGWR-NH2 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed