BDBM320732 (R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)-2- methylpropyl)-6- (dimethylamino)-3- (hydroxymethyl)-1H- pyrazolo[3,4-d]pyrimidin- 4(5H)-one::US10174037, Example 138::US10174037, Example 139

SMILES CC(C)C(c1ccc(cc1)C(C)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C

InChI Key InChIKey=ODZGWLBZADADEQ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 320732   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320732(US10174037, Example 139 | (R)- or (S)-1-(1-(4-(1,1...)
Affinity DataKi:  0.0400nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320732(US10174037, Example 139 | (R)- or (S)-1-(1-(4-(1,1...)
Affinity DataKi:  0.0640nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320732(US10174037, Example 139 | (R)- or (S)-1-(1-(4-(1,1...)
Affinity DataKi:  0.190nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320732(US10174037, Example 139 | (R)- or (S)-1-(1-(4-(1,1...)
Affinity DataKi:  0.410nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In DepthDetails
US Patent