BDBM318842 6-(4-chlorophenyl)-3-cyclopropyl-5-(3-(difluoromethyl)-8-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-methyl-5,6-dihydropyrrolo[3,4-c]pyrazol-4(1H)-one::US9624247, Example 4

SMILES COCCn1nc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1

InChI Key InChIKey=SCOGYYPZUPWMLU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 318842   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandPNGBDBM318842(US9624247, Example 4 | 6-(4-chlorophenyl)-3-cyclop...)
Affinity DataIC50: 11nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandPNGBDBM318842(US9624247, Example 4 | 6-(4-chlorophenyl)-3-cyclop...)
Affinity DataIC50: 17nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM318842(US9624247, Example 4 | 6-(4-chlorophenyl)-3-cyclop...)
Affinity DataIC50: 11nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM318842(US9624247, Example 4 | 6-(4-chlorophenyl)-3-cyclop...)
Affinity DataIC50: 7.30E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent