BDBM31809 Apogossypol derivative, 8k

SMILES CC(NC(=O)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(=O)NC(C)c3ccc(Cl)cc3)c(O)c(O)cc2c1O)c1ccc(Cl)cc1

InChI Key InChIKey=GWXWVWQUYKMTOZ-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31809   

TargetBcl-2-like protein 1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31809(Apogossypol derivative, 8k)
Affinity DataIC50: 270nM Kd:  110nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31809(Apogossypol derivative, 8k)
Affinity DataIC50: 490nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31809(Apogossypol derivative, 8k)
Affinity DataIC50: 230nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31809(Apogossypol derivative, 8k)
Affinity DataIC50: 400nMT: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetBcl-2 homologous antagonist/killer(Human)
National University of Ireland Galway

Curated by ChEMBL
LigandPNGBDBM31809(Apogossypol derivative, 8k)
Affinity DataIC50: 230nMAssay Description:Inhibition of Mcl-1/Bak (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed