BDBM317642 US11337976, Compound P-0013::US20230277534, Compound P-0013::US9624213, Compound P-0013

SMILES CCN(C)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F

InChI Key InChIKey=AQEMAIVZOAKYQG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 317642   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Plexxikon

US Patent
LigandPNGBDBM317642(US9624213, Compound P-0013 | US11337976, Compound ...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Plexxikon

US Patent
LigandPNGBDBM317642(US9624213, Compound P-0013 | US11337976, Compound ...)
Affinity DataIC50: 100nMAssay Description:For example, the biochemical activity IC50 values are determined with respect to inhibition of B-Raf V600E kinase activity or p-Erk kinase activity, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Plexxikon

US Patent
LigandPNGBDBM317642(US9624213, Compound P-0013 | US11337976, Compound ...)
Affinity DataIC50: 100nMAssay Description:The biochemical activity IC50 values are determined with respect to inhibition of B-Raf V600E kinase activity or p-Erk kinase activity, where inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
University of Orleans

Curated by ChEMBL
LigandPNGBDBM317642(US9624213, Compound P-0013 | US11337976, Compound ...)
Affinity DataIC50: 690nMAssay Description:Inhibition of wild type B-RAF (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Orleans

Curated by ChEMBL
LigandPNGBDBM317642(US9624213, Compound P-0013 | US11337976, Compound ...)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed