BDBM317622 3-(2-{5- Amino-1-[4- (2,3-difluoro- phenoxy)-2- methyl- phenyl]-1H- pyrazole-4- carbonyl}-1H- indol-4-yl)- benzonitrile::US10640491, Compound 11::US11104668, Compound 11::US9624201, Compound 11

SMILES Cc1cc(Oc2cccc(F)c2F)ccc1-n1ncc(C(=O)c2cc3c(cccc3[nH]2)-c2cccc(c2)C#N)c1N

InChI Key InChIKey=NAWHEYDAFLUHAV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 317622   

TargetTyrosine-protein kinase BTK(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM317622(US9624201, Compound 11 | 3-(2-{5- Amino-1-[4- (2,3...)
Affinity DataIC50: 59.1nMAssay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of Btk, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM317622(US9624201, Compound 11 | 3-(2-{5- Amino-1-[4- (2,3...)
Affinity DataIC50: 59.1nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Flouresence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM317622(US9624201, Compound 11 | 3-(2-{5- Amino-1-[4- (2,3...)
Affinity DataIC50: 59.1nMAssay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
Go to US Patent