BDBM317453 BDBM50165434::US9617250, Example 1 Example 204 of D1

SMILES CCC(CC)c1cc(cc(C)n1)-c1nc(no1)-c1cc(C)c(OC[C@@H](O)CNC(=O)CO)c(CC)c1

InChI Key InChIKey=CHIUPZSZKBJIHD-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 317453   

TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM317453(US9617250, Example 1 Example 204 of D1 | BDBM50165...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human recombinant S1PR1 expressed in CHO cell membranes assessed as [35S]GTPgammaS binding preincubated for 30 mins followed by [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM317453(US9617250, Example 1 Example 204 of D1 | BDBM50165...)
Affinity DataEC50:  0.200nMAssay Description:GTPγS binding assays are performed in 96 well microtiter plates (Nunc, 442587) in a final volume of 200 μl, using membrane preparations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM317453(US9617250, Example 1 Example 204 of D1 | BDBM50165...)
Affinity DataEC50:  44nMAssay Description:GTPγS binding assays are performed in 96 well microtiter plates (Nunc, 442587) in a final volume of 200 μl, using membrane preparations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM317453(US9617250, Example 1 Example 204 of D1 | BDBM50165...)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in CHO cells incubated for 30 mins prior to [35S]-GTPgammaS addition measured after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM317453(US9617250, Example 1 Example 204 of D1 | BDBM50165...)
Affinity DataEC50:  46nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to [35S]-GTPgammaS addition measured after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed