BDBM316964 N-[2,4-Difluoro-3-(4- isobutyl-7H-pyrrolo[2,3- d]pyrimidine-5-carbonyl)- phenyl]-4-trifluoromethyl- benzenesulfonamide::US9617267, Compound P-1015

SMILES CC(C)Cc1ncnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4ccc(cc4)C(F)(F)F)c3F)c12

InChI Key InChIKey=KYWSYAMZKOEFFP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 316964   

TargetSerine/threonine-protein kinase B-raf(Human)
Plexxikon

US Patent
LigandPNGBDBM316964(US9617267, Compound P-1015 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetEpidermal growth factor receptor [T790M,L858R](Human)
Plexxikon

US Patent
LigandPNGBDBM316964(US9617267, Compound P-1015 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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LigandPNGBDBM316964(US9617267, Compound P-1015 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Plexxikon

US Patent
LigandPNGBDBM316964(US9617267, Compound P-1015 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetCytochrome P450 2C19(Human)
Plexxikon

US Patent
LigandPNGBDBM316964(US9617267, Compound P-1015 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetCytochrome P450 2C9(Human)
Plexxikon

US Patent
LigandPNGBDBM316964(US9617267, Compound P-1015 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetCytochrome P450 2D6(Human)
Plexxikon

US Patent
LigandPNGBDBM316964(US9617267, Compound P-1015 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
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TargetCytochrome P450 3A4(Human)
Plexxikon

US Patent
LigandPNGBDBM316964(US9617267, Compound P-1015 | N-[2,4-Difluoro-3-(4-...)
Affinity DataIC50: 7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent