BDBM316955 N-[3-(4-Ethoxy-7H- pyrrolo[2,3-d]pyrimidine-5- carbonyl)-2,4-difluoro- phenyl]-4-trifluoromethyl- benzenesulfonamide::US9617267, Compound P-1006

SMILES CCOc1ncnc2[nH]cc(C(=O)c3c(F)ccc(NS(=O)(=O)c4ccc(cc4)C(F)(F)F)c3F)c12

InChI Key InChIKey=DCLSEMSHYVMKNE-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 316955   

TargetSerine/threonine-protein kinase B-raf(Human)
Plexxikon

US Patent
LigandPNGBDBM316955(US9617267, Compound P-1006 | N-[3-(4-Ethoxy-7H- py...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Plexxikon

US Patent
LigandPNGBDBM316955(US9617267, Compound P-1006 | N-[3-(4-Ethoxy-7H- py...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM316955(US9617267, Compound P-1006 | N-[3-(4-Ethoxy-7H- py...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 1A2(Human)
Plexxikon

US Patent
LigandPNGBDBM316955(US9617267, Compound P-1006 | N-[3-(4-Ethoxy-7H- py...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 2C19(Human)
Plexxikon

US Patent
LigandPNGBDBM316955(US9617267, Compound P-1006 | N-[3-(4-Ethoxy-7H- py...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 2C9(Human)
Plexxikon

US Patent
LigandPNGBDBM316955(US9617267, Compound P-1006 | N-[3-(4-Ethoxy-7H- py...)
Affinity DataIC50: 7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 2D6(Human)
Plexxikon

US Patent
LigandPNGBDBM316955(US9617267, Compound P-1006 | N-[3-(4-Ethoxy-7H- py...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 3A4(Human)
Plexxikon

US Patent
LigandPNGBDBM316955(US9617267, Compound P-1006 | N-[3-(4-Ethoxy-7H- py...)
Affinity DataIC50: 5.00E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 3A4(Human)
Plexxikon

US Patent
LigandPNGBDBM316955(US9617267, Compound P-1006 | N-[3-(4-Ethoxy-7H- py...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails
US Patent