BDBM315178 (3R/S)-3-[3-({(2R/S)-2-[4-(5-Chloro-6-methylpyridin-3-yl)-3-fluorophenyl]-2-cyclopentylacetyl}amino)-2-methylphenyl]butanoic acid::US10172814, Example 120::US10172814, Example 121::US10172814, Example 122::US10172814, Example 123::US10172814, Example 124

SMILES CC(CC(O)=O)c1cccc(NC(=O)C(C2CCCC2)c2ccc(c(F)c2)-c2cnc(C)c(Cl)c2)c1C

InChI Key InChIKey=WVFCPUMLDXWLRI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 315178   

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315178((3R/S)-3-[3-({(2R/S)-2-[4-(5-Chloro-6-methylpyridi...)
Affinity DataIC50: 15.9nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315178((3R/S)-3-[3-({(2R/S)-2-[4-(5-Chloro-6-methylpyridi...)
Affinity DataIC50: 382nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315178((3R/S)-3-[3-({(2R/S)-2-[4-(5-Chloro-6-methylpyridi...)
Affinity DataIC50: 22.8nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315178((3R/S)-3-[3-({(2R/S)-2-[4-(5-Chloro-6-methylpyridi...)
Affinity DataIC50: 646nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315178((3R/S)-3-[3-({(2R/S)-2-[4-(5-Chloro-6-methylpyridi...)
Affinity DataIC50: 5.06nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent