BDBM314856 (R/S) 3-[3-({[4-(5-Chloropyridin-3-yl)phenyl](cyclopentyl)acetyl}amino)-6-methoxy-2-methylphenyl]propanoic acid::US10172814, Example 38::US10172814, Example 39

SMILES COc1ccc(NC(=O)C(C2CCCC2)c2ccc(cc2)-c2cncc(Cl)c2)c(C)c1CCC(O)=O

InChI Key InChIKey=RWXYPGOFFKXNHR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 314856   

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM314856(US10172814, Example 39 | (R/S) 3-[3-({[4-(5-Chloro...)
Affinity DataIC50: 46.2nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM314856(US10172814, Example 39 | (R/S) 3-[3-({[4-(5-Chloro...)
Affinity DataIC50: 14.3nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin E synthase(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM314856(US10172814, Example 39 | (R/S) 3-[3-({[4-(5-Chloro...)
Affinity DataIC50: 46nMAssay Description:Inhibition of human recombinant FLAG-tagged PTGES expressed in baculovirus infected Hi-5 insect cells using prostaglandin H2 as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed