BDBM313807 US10167292, Example 51B

SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1nn[nH]n1

InChI Key InChIKey=QDOKVLKQKZPGPG-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 313807   

TargetBromodomain-containing protein 2 [91-163](Human)
Catalyst Therapeutics

US Patent
LigandPNGBDBM313807(US10167292, Example 51B)
Affinity DataIC50: 100nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 2 [364-436](Human)
Catalyst Therapeutics

US Patent
LigandPNGBDBM313807(US10167292, Example 51B)
Affinity DataIC50: 100nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Catalyst Therapeutics

US Patent
LigandPNGBDBM313807(US10167292, Example 51B)
Affinity DataIC50: 100nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Catalyst Therapeutics

US Patent
LigandPNGBDBM313807(US10167292, Example 51B)
Affinity DataIC50: 100nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBromodomain-containing protein 2(Human)
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313807(US10167292, Example 51B)
Affinity DataIC50: 7nMAssay Description:Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313807(US10167292, Example 51B)
Affinity DataIC50: 3nMAssay Description:Inhibition of human His-tagged Brd4 bromodomain 1 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 2(Human)
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313807(US10167292, Example 51B)
Affinity DataIC50: 6nMAssay Description:Inhibition of human His-tagged Brd2 bromodomain 1 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313807(US10167292, Example 51B)
Affinity DataIC50: 2nMAssay Description:Inhibition of human His-tagged Brd4 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed