BDBM313794 US10167292, Example 38

SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(=O)NC(c1ccccc1)c1ccccc1

InChI Key InChIKey=GPVRSQMGHNALCJ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 313794   

TargetBromodomain-containing protein 2 [91-163](Human)
Catalyst Therapeutics

US Patent
LigandPNGBDBM313794(US10167292, Example 38)
Affinity DataIC50: 550nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [364-436](Human)
Catalyst Therapeutics

US Patent
LigandPNGBDBM313794(US10167292, Example 38)
Affinity DataIC50: 100nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
Catalyst Therapeutics

US Patent
LigandPNGBDBM313794(US10167292, Example 38)
Affinity DataIC50: 100nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Catalyst Therapeutics

US Patent
LigandPNGBDBM313794(US10167292, Example 38)
Affinity DataIC50: 100nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Catalyst Therapeutics

US Patent
LigandPNGBDBM313794(US10167292, Example 38)
Affinity DataIC50: 100nMAssay Description:BRD binding and inhibition was assessed by measuring the interaction of biotinylated acetyl-histone H4 peptide (Anaspec #64989) with the BRD target p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2(Human)
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313794(US10167292, Example 38)
Affinity DataIC50: 44nMAssay Description:Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313794(US10167292, Example 38)
Affinity DataIC50: 44nMAssay Description:Inhibition of human His-tagged Brd4 bromodomain 1 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313794(US10167292, Example 38)
Affinity DataIC50: 151nMAssay Description:Inhibition of human His-tagged Brd2 bromodomain 1 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313794(US10167292, Example 38)
Affinity DataIC50: 14nMAssay Description:Inhibition of human His-tagged Brd4 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM313794(US10167292, Example 38)
Affinity DataIC50: 39nMAssay Description:Inhibition of human His-tagged Brd3 bromodomain 1 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2020
Entry Details Article
PubMed