BDBM313751 US10167282, Compound TBAP-02

SMILES Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)C(C)(C)C

InChI Key InChIKey=BPLDYDVBIOFLJB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 313751   

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM313751(US10167282, Compound TBAP-02)
Affinity DataIC50: 99nMAssay Description:V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM313751(US10167282, Compound TBAP-02)
Affinity DataIC50: 12nMAssay Description:Mutant BRAF WM266.4 Cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM313751(US10167282, Compound TBAP-02)
Affinity DataIC50: 6.50E+4nMAssay Description:Studies were conducted at Cyprotex Discovery in Cheshire, UK according to the contractor's protocol. The studies were performed on an IonWorks HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent