BDBM313486 N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxypyridin-3- yl)-4-methylphenyl)-2- (trifluoromethyl)isonicotin- amide::US10167279, Example 105

SMILES COc1ncc(cc1C1(CF)COC1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C

InChI Key InChIKey=LMKSNXQADYFDKA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313486   

LigandPNGBDBM313486(N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxyp...)
Affinity DataIC50: 91.5nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
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LigandPNGBDBM313486(N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxyp...)
Affinity DataIC50: 323nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent