BDBM313485 N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxypyridin-3- yl)-4-methylphenyl)-2- (2-fluoropropan-2- yl)isonicotinamide::US10167279, Example 104

SMILES COc1ncc(cc1C1(CF)COC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)F)ccc1C

InChI Key InChIKey=HJEKGKRDJAZOEN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313485   

LigandPNGBDBM313485(N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxyp...)
Affinity DataIC50: 128nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
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LigandPNGBDBM313485(N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxyp...)
Affinity DataIC50: 417nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent