BDBM312764 1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin-3- yl]ethynyl]phenyl]pyrazolo [3,4-b]pyridine-3-carboxamide::US10550117, Compound C-1::US9605005, Example 53

SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cccnc23)C1=O

InChI Key InChIKey=QRHDTFFVGFIUKH-UHFFFAOYSA-N

Data  5 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 312764   

LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of NIK (unknown origin) expressed in HEK293 cells harboring NFkB-Luc assessed as reduction in NFkB signal after 24 hrs by luciferase repor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of NIK in HEK-293 cells assessed as inhibition of NIK-dependent NF-kappaB response element expression by firefly luciferase reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of NIK in HUVEC cells assessed as inhibition of anti-LTf3R-stimulated p52 nuclear translocationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PKD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.0800nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.170nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of NIK (unknown origin) catalyzed ATP hydrolysis assessed as inhibition constant by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPolycystin-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  89nMAssay Description:Inhibition of PKD1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed