BDBM312151 (E)-6,8-dihydroxy-2-(4-hydroxyphenyl)-4-(prop-1-enyl)isoquinolin-1(2H)-one ::US9604931, 15i::US9623021, Compound 15i

SMILES C\C=C\c1cn(-c2ccc(O)cc2)c(=O)c2c(O)cc(O)cc12

InChI Key InChIKey=QAGWYKCFYYZWRQ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 312151   

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312151(US9604931, 15i | (E)-6,8-dihydroxy-2-(4-hydroxyphe...)
Affinity DataKi:  1.66nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent

TargetEstrogen receptor beta(Human)
Gtx

US Patent
LigandPNGBDBM312151(US9604931, 15i | (E)-6,8-dihydroxy-2-(4-hydroxyphe...)
Affinity DataKi:  1.66nMAssay Description:Recombinant ER-α or ER-β ligand binding domain (LBD) was combined with [3H]E2 (PerkinElmer, Waltham, Mass.) in buffer A (10 mM Tris, pH 7.4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetSteroid hormone receptor ERR1(Human)
Gtx

US Patent
LigandPNGBDBM312151(US9604931, 15i | (E)-6,8-dihydroxy-2-(4-hydroxyphe...)
Affinity DataKi:  102nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Gtx

US Patent
LigandPNGBDBM312151(US9604931, 15i | (E)-6,8-dihydroxy-2-(4-hydroxyphe...)
Affinity DataKi:  102nMAssay Description:Recombinant ER-α or ER-β ligand binding domain (LBD) was combined with [3H]E2 (PerkinElmer, Waltham, Mass.) in buffer A (10 mM Tris, pH 7.4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent