BDBM311486 CHEM-US-00192::US10155764, Example 65B

SMILES C[C@@H](Nc1nn(C)c(=O)c2cccnc12)[C@H](N(C)C)c1ccccc1

InChI Key InChIKey=OFKKYVMUDLMESU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 311486   

TargetHistone acetyltransferase KAT2B [719-832](Human)
Genentech

US Patent
LigandPNGBDBM311486(US10155764, Example 65B | CHEM-US-00192)
Affinity DataIC50: 19nMAssay Description:His/Flag epitope tagged PCAF719-832 bromodomain was cloned, expressed and purified to homogeneity in-house. PCAF bromodomain binding and inhibition o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM311486(US10155764, Example 65B | CHEM-US-00192)
Affinity DataIC50: 19nMAssay Description:Displacement of biotinylated small molecule ligand from His/FLAG-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) after 15 mins by Alph...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM311486(US10155764, Example 65B | CHEM-US-00192)
Affinity DataIC50: 19nMAssay Description:Inhibition of biotinylated ligand binding to FLAG epitope-fused/His-tagged PCAF bromodomain (719 to 832 residues) (unknown origin) measured after 15 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM311486(US10155764, Example 65B | CHEM-US-00192)
Affinity DataIC50: 19nMAssay Description:Inhibition of PCAF bromodomain/GCN5 bromodomain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed