BDBM311193 (S)-1-(2-(difluoromethyl)-4-(2-(difluoromethyl)pyridin-4-yl)phenoxy)-2,4-dimethylpentan-2-amine::US10155760, Example 37::US10351563, Example 37::US10544120, Example 37::US10723734, Example 37::US10981910, Example 37::US9902722, Example 37

SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)F)-c1ccnc(c1)C(F)F

InChI Key InChIKey=NGBWQVJCOYTGOR-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 311193   

TargetBMP-2-inducible protein kinase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 280nMAssay Description:Inhibition of BIKE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of AAK1 expressed in human HEK293K cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of AAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 420nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 440nMAssay Description:Inhibition of PRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetcGMP-dependent protein kinase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 420nMAssay Description:Inhibition of PKG2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 180nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCitron Rho-interacting kinase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 56nMAssay Description:Inhibition of CRIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 73nMAssay Description:Inhibition of GAK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.510nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BFC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of AKK1 in HEK293F cells assessed as reduction in phospho mu2 formation incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.510nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.510nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 Cl prepared from 15 μl additions of enzyme and substrates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.510nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.510nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2020
Entry Details
Go to US Patent

TargetAP2-associated protein kinase 1(Human)
Sichuan Univiersity

Curated by ChEMBL
LigandPNGBDBM311193(US10155760, Example 37 | (S)-1-(2-(difluoromethyl)...)
Affinity DataIC50: 0.510nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent