BDBM310898 N,N-dimethyl-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide::US10150767, Example 22

SMILES CN(C)C(=O)c1cccc(c1)-c1cn(C)c(=O)c2[nH]ccc12

InChI Key InChIKey=YHMNROQTPUKNLA-UHFFFAOYSA-N

Data  38 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 310898   

TargetTranscription intermediary factor 1-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 910nMAssay Description:Binding affinity to human partial length TRIM24 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase p300(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 270nMAssay Description:Binding affinity to human partial length EP300 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 3.60E+3nMAssay Description:Binding affinity to human partial length BAZ2B expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 9.00E+3nMAssay Description:Binding affinity to human partial length SMARCA4 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 230nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRD9 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 560nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 7.60E+3nMAssay Description:Binding affinity to human partial length PBRM1(2) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeregrin(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRPF1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeregrin(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRPF1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 880nMAssay Description:Binding affinity to human partial length BAZ2A expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein polybromo-1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 7.60E+3nMAssay Description:Binding affinity to human partial length PBRM1(2) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 6.70E+3nMAssay Description:Binding affinity to human partial length SMARCA2 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 6.70E+3nMAssay Description:Binding affinity to human partial length SMARCA2 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone acetyltransferase p300(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 270nMAssay Description:Binding affinity to human partial length EP300 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant His-tagged CBP (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant His-tagged BRD9 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 880nMAssay Description:Binding affinity to human partial length BAZ2A expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 910nMAssay Description:Binding affinity to human partial length TRIM24 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 53nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 3.60E+3nMAssay Description:Binding affinity to human partial length BAZ2B expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTranscription activator BRG1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 9.00E+3nMAssay Description:Binding affinity to human partial length SMARCA4 expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 230nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRD9 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 560nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM310898(US10150767, Example 22 | N,N-dimethyl-3-(6-methyl-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)