BDBM310661 (S)-(5-(2-Chloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-(3-hydroxy-3-(2-hydroxypropan-2-yl)azetidine-1-carbonyl)thiazol-4-yl)(2-methylpyrrolidin-1-yl)methanone::US10150762, Example 10/3

SMILES C[C@H]1CCCN1C(=O)c1nc(sc1-c1ccc(cc1Cl)C(O)(C(F)(F)F)C(F)(F)F)C(=O)N1CC(O)(C1)C(C)(C)O

InChI Key InChIKey=GMLRWPKZEVLFGF-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 310661   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310661(US10150762, Example 10/3 | (S)-(5-(2-Chloro-4-(1,1...)
Affinity DataKd:  2.5nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310661(US10150762, Example 10/3 | (S)-(5-(2-Chloro-4-(1,1...)
Affinity DataIC50: 32nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent