BDBM310659 (4-(7-Azabicyclo[2.2.1]heptane-7-carbonyl)-5-(2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)thiazol-2-yl)((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)methanone::US10150762, Example 10/1

SMILES O[C@H]1CN(C[C@H]1O)C(=O)c1nc(C(=O)N2C3CCC2CC3)c(s1)-c1ccc(c(Cl)c1Cl)C(O)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=BNVGNLYOSLASJY-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 310659   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310659(US10150762, Example 10/1 | (4-(7-Azabicyclo[2.2.1]...)
Affinity DataKd:  26nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310659(US10150762, Example 10/1 | (4-(7-Azabicyclo[2.2.1]...)
Affinity DataIC50: 120nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent