BDBM310643 4-(4-(7-Azabicyclo[2.2.1]heptane-7-carbonyl)-5-(2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)thiazole-2-carbonyl)piperazin-2-one::US10150762, Example 3/10

SMILES OC(c1ccc(-c2sc(nc2C(=O)N2C3CCC2CC3)C(=O)N2CCNC(=O)C2)c(Cl)c1Cl)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=ZUBLNHDOZBRIND-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 310643   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310643(US10150762, Example 3/10 | 4-(4-(7-Azabicyclo[2.2....)
Affinity DataKd:  24nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310643(US10150762, Example 3/10 | 4-(4-(7-Azabicyclo[2.2....)
Affinity DataIC50: 130nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent