BDBM308239 US9650377, Example 126

SMILES CC(C)(C)[Si](OCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C2=C1)C1CC1)(c1ccccc1)c1ccccc1

InChI Key InChIKey=DBSRCEYBLWCRLN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 308239   

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM308239(US9650377, Example 126)
Affinity DataIC50: 6nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
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TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandPNGBDBM308239(US9650377, Example 126)
Affinity DataIC50: 712nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
Go to US Patent