BDBM308098 US9650377, Example 32

SMILES Cn1cc(cn1)C1=NCC(=O)N2CCc3c(I)cccc3C2=C1

InChI Key InChIKey=GGNUBGHBZKNFOS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 308098   

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM308098(US9650377, Example 32)
Affinity DataIC50: 10nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandPNGBDBM308098(US9650377, Example 32)
Affinity DataIC50: 35nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
Go to US Patent