BDBM304414 3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-((5-methyl-1,1-dioxido-4,5-dihydrobenzo[f][1,2,5]thiadiazepin-2(3H)-yl)methyl)phenyl)propanoic acid::US10144731, Example 1

SMILES COc1cc(cc2nnn(C)c12)C(CC(O)=O)c1ccc(C)c(CN2CCN(C)c3ccccc3S2(=O)=O)c1

InChI Key InChIKey=IJHWQGAWCBWPSG-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 304414   

TargetNuclear factor erythroid 2-related factor 2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM304414(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Affinity DataEC50:  5.50E+3nMAssay Description:NAD(P)H:quinone oxidoreductase 1 (NQO1), also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependen...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetKelch-like ECH-associated protein 1 [321-609](Human)
Glaxosmithkline

US Patent
LigandPNGBDBM304414(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Affinity DataIC50: 55nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetKelch-like ECH-associated protein 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM304414(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Affinity DataIC50: 37nMAssay Description:Displacement of 5'-TAMRA-labelled NRF2 peptide from human N-terminal His6-tagged KEAP1 Kelch domain (321 to 609 residues) expressed in baculovirus in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM304414(3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-...)
Affinity DataEC50:  570nMAssay Description:Activation of Nrf2 in human BEAS2B cells assessed as increase in NQO1 enzymatic activity measured after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed