BDBM304252 US10143695, Compound 69

SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O

InChI Key InChIKey=PRRHJTRIZWFLDA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 304252   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304252(US10143695, Compound 69)
Affinity DataIC50: 4.70nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304252(US10143695, Compound 69)
Affinity DataIC50: 1.5nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304252(US10143695, Compound 69)
Affinity DataIC50: 3nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304252(US10143695, Compound 69)
Affinity DataIC50: 1.5nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Mersana Therapeutics

US Patent
LigandPNGBDBM304252(US10143695, Compound 69)
Affinity DataIC50: 69nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
In DepthDetails
US Patent