BDBM303533 US10138229, Example 44::US10875852, Example 44::US9926299, 31

SMILES NC(=O)c1c(N)n(CCNC(=O)C=C)nc1-c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=NPDZKGGNKBHORD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 303533   

TargetTyrosine-protein kinase BTK(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM303533(US10138229, Example 44 | US9926299, 31 | US1087585...)
Affinity DataIC50: 1nMAssay Description:TBDAn HTRF assay (Cisbio KinEASE-TK cat #62TKOPEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM303533(US10138229, Example 44 | US9926299, 31 | US1087585...)
Affinity DataIC50: 100nMAssay Description:Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM303533(US10138229, Example 44 | US9926299, 31 | US1087585...)
Affinity DataIC50: 1nMAssay Description:An HTRF assay (Cisbio KinEASE-TK cat #62TK0PEC) was performed to quantitate the ability of test compounds to inhibit BTK mediated phosphorylation of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent