BDBM30283 indole-based 6-membered lactam, 2

SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCn3c2c1

InChI Key InChIKey=YMFJIJWPXNXALF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 30283   

TargetMAP kinase-activated protein kinase 2 [41-364](Human)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30283(indole-based 6-membered lactam, 2)
Affinity DataIC50: 1.70E+3nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2009
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM30283(indole-based 6-membered lactam, 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RSK2-mediated CREB phosphorylation in HeLa cells expressing luciferase reporter geneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM30283(indole-based 6-membered lactam, 2)
Affinity DataIC50: 730nMAssay Description:Inhibition of RSK2 phosphorylation by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed