BDBM301973 2-(4-(4-(5-Fluoro-1H-indol-3-yl)butyl)piperazin-1-yl)pyrimidine-4-carboxamide::US9598401, Example 27

SMILES NC(=O)c1ccnc(n1)N1CCN(CCCCc2c[nH]c3ccc(F)cc23)CC1

InChI Key InChIKey=QHAYZSOGWQMJOL-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 301973   

Target5-hydroxytryptamine receptor 1A(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM301973(2-(4-(4-(5-Fluoro-1H-indol-3-yl)butyl)piperazin-1-...)
Affinity DataKi:  60nMAssay Description:Human HEK-293 cell homogenates (36 μg protein) were incubated at 22° C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM301973(2-(4-(4-(5-Fluoro-1H-indol-3-yl)butyl)piperazin-1-...)
Affinity DataKi: >1.00E+3nMAssay Description:Cell membrane homogenates (24 μg protein) were incubated at 22° C. for 60 minutes with 0.3 nM [3H]methyl-spiperone in the absence or presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent