BDBM3008 3,4-Bis((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine::3-N,4-N-bis(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine::4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 9

SMILES Clc1cccc(Nc2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)c1

InChI Key InChIKey=URVRJEIGGRSCLI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 3008   

TargetEpidermal growth factor receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM3008(3-N,4-N-bis(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyri...)
Affinity DataIC50: 33nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2005
Entry Details Article
PubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Novartis Pharmaceuticals

LigandPNGBDBM3008(3-N,4-N-bis(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyri...)
Affinity DataIC50: 1.98E+3nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Pharmaceuticals

LigandPNGBDBM3008(3-N,4-N-bis(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyri...)
Affinity DataIC50: 5.30E+3nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2005
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Bovine)
Novartis Pharmaceuticals

LigandPNGBDBM3008(3-N,4-N-bis(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyri...)
Affinity DataIC50: 5.90E+3nMpH: 7.5Assay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2005
Entry Details Article
PubMed