BDBM300509 4-chloro-N-[6-(2-fluorophenyl)pyridin-3-yl]-3-({[1-(morpholin-4-yl)cyclopropyl]carbonyl}amino)benzamide::US10130633, Example 79

SMILES O=C(Nc2ccc(c1ccccc1F)nc2)c5ccc(Cl)c(NC(=O)C4(N3CCOCC3)CC4)c5

InChI Key InChIKey=PYKWRQILRWMKNC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 300509   

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300509(4-chloro-N-[6-(2-fluorophenyl)pyridin-3-yl]-3-({[1...)
Affinity DataIC50: 20.4nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300509(4-chloro-N-[6-(2-fluorophenyl)pyridin-3-yl]-3-({[1...)
Affinity DataIC50: 64nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before beginning the test at 10000 cells per well in a 384 micro titre plate (MT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300509(4-chloro-N-[6-(2-fluorophenyl)pyridin-3-yl]-3-({[1...)
Affinity DataIC50: 1.50E+4nMAssay Description:HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300509(4-chloro-N-[6-(2-fluorophenyl)pyridin-3-yl]-3-({[1...)
Affinity DataIC50: 5.00E+4nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent