BDBM300500 N-[6-(3-fluorophenyl)pyridin-3-yl]-3-{[2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)propanoyl]amino}-4-(trifluoromethoxy)benzamide::US10130633, Example 70

SMILES CC(C(=O)Nc3cc(C(=O)Nc2ccc(c1cccc(F)c1)nc2)ccc3OC(F)(F)F)N4CC5CCC(C4)O5

InChI Key InChIKey=XTYSNFAOAGFDBE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 300500   

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300500(N-[6-(3-fluorophenyl)pyridin-3-yl]-3-{[2-(8-oxa-3-...)
Affinity DataIC50: 24nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300500(N-[6-(3-fluorophenyl)pyridin-3-yl]-3-{[2-(8-oxa-3-...)
Affinity DataIC50: 4.60E+3nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300500(N-[6-(3-fluorophenyl)pyridin-3-yl]-3-{[2-(8-oxa-3-...)
Affinity DataIC50: 85nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before beginning the test at 10000 cells per well in a 384 micro titre plate (MT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300500(N-[6-(3-fluorophenyl)pyridin-3-yl]-3-{[2-(8-oxa-3-...)
Affinity DataIC50: 6.30E+3nMAssay Description:HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent