BDBM300427 US10130622, Example 00006

SMILES COCCS(=O)(=O)NC(=O)c1cc(N2CCC(CC2)OC)c2c(nn(-c3ccccc3)c2n1)C1CCC1

InChI Key InChIKey=PPNWCONNYOQLSG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 300427   

LigandPNGBDBM300427(US10130622, Example 00006)
Affinity DataIC50: 417nMAssay Description:YFP-Halide Influx Assay for the CFTR-ΔF508 Mutation and Suppressor mutants (I539T or G550E)The YFP halide influx assay measures the functionalit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Abbvie S.á.R.L.

US Patent
LigandPNGBDBM300427(US10130622, Example 00006)
Affinity DataIC50: 6.67E+3nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Abbvie S.á.R.L.

US Patent
LigandPNGBDBM300427(US10130622, Example 00006)
Affinity DataIC50: 104nMAssay Description:For this purpose, HEK293 cells are transfected with plasmid DNA containing WT CFTR and seeded in 96 well plates (70,000 HEK cells/well). Two days aft...More data for this Ligand-Target Pair
In DepthDetails
US Patent