BDBM29768 hydroxyethylamine derivative, 22

SMILES CCc1ccnc2c(cc(cc12)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1cccc(c1)C(F)(F)F)N1CCCC1=O

InChI Key InChIKey=YDNCUOPJVVQEMT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29768   

TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM29768(hydroxyethylamine derivative, 22)
Affinity DataIC50: 210nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM29768(hydroxyethylamine derivative, 22)
Affinity DataIC50: 1.32E+4nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM29768(hydroxyethylamine derivative, 22)
Affinity DataIC50: 1.44E+4nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed