BDBM297345 N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)cyclopropanecarboxamide (Cpd. No. 12)::US10112955, Example 12

SMILES O=C(Nc1cc(Nc2ccc3C(=O)NCc3c2)ncn1)C1CC1

InChI Key InChIKey=MIVZVCNGBMCBAA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 297345   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM297345(US10112955, Example 12 | N-(6-((1-oxoisoindolin-5-...)
Affinity DataIC50: 10nMAssay Description:Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM297345(US10112955, Example 12 | N-(6-((1-oxoisoindolin-5-...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM297345(US10112955, Example 12 | N-(6-((1-oxoisoindolin-5-...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM297345(US10112955, Example 12 | N-(6-((1-oxoisoindolin-5-...)
Affinity DataIC50: 430nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM297345(US10112955, Example 12 | N-(6-((1-oxoisoindolin-5-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM297345(US10112955, Example 12 | N-(6-((1-oxoisoindolin-5-...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of Mnk2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics

US Patent
LigandPNGBDBM297345(US10112955, Example 12 | N-(6-((1-oxoisoindolin-5-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of Mnk1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM297345(US10112955, Example 12 | N-(6-((1-oxoisoindolin-5-...)
Affinity DataIC50: 430nMAssay Description:Inhibition of phosphorylation of eIF4E (unknown origin) in HCT-116 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed