BDBM296869 BDBM376389::US10111866, Example 2::US10292975, Example 2::US10709695, Example 2

SMILES CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(OCCN(C)C)cc(c2)C(F)(F)F)c(F)c1

InChI Key InChIKey=JCPFDKWEHMBUPR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 296869   

LigandPNGBDBM296869(US10709695, Example 2 | US10111866, Example 2 | BD...)
Affinity DataIC50: 10nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM296869(US10709695, Example 2 | US10111866, Example 2 | BD...)
Affinity DataIC50: 10nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM296869(US10709695, Example 2 | US10111866, Example 2 | BD...)
Affinity DataIC50: 10nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM296869(US10709695, Example 2 | US10111866, Example 2 | BD...)
Affinity DataIC50: 10nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In DepthDetails
US Patent