BDBM296259 US10112937, Example 349

SMILES C[C@H]1Cc2c(CN1C(=O)c1cccc(c1F)C(F)(F)F)nnn2-c1ccn[nH]1

InChI Key InChIKey=JWJNXWJNUVFQCA-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 296259   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM296259(US10112937, Example 349)
Affinity DataIC50: 2.70nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM296259(US10112937, Example 349)
Affinity DataIC50: 2.20nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM296259(US10112937, Example 349)
Affinity DataKi:  7.90nMAssay Description:uman or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according t...More data for this Ligand-Target Pair
In DepthDetails
US Patent